Forced overexpression of EphA2 resulted in malignant transformation of non-transformed MCF10A breast cells [16], whereas Conversely, siRNA-mediated inhibition of EphA2 or overexpression of dominant-negative EphA2 constructs suppressed growth and metastasis of MMTV-Neu tumor cells and 4T1 metastatic mouse mammary adenocarcinoma cells, respectively, in vivo[18], [19]. Here, EPHA2 is linked to neoplasm.