Furthermore, 13.9% of the tumor in the Ctrl group contained between 11 and 50 CD4+ cells per microscopic field compared to 4.3%, 6.2% and 1.8% respectively for the mice in which IL-18, IFN-γ, or both were neutralized (Fig. 2 C and Fig. 3 C & D). This evidence concerns the gene IL18 and neoplasm.