Furthermore, whilst several reports compare the in vivo growth characteristics of derivative cell lines transfected with different constructs to demonstrate the tumor suppressive effects of IL-18 [20], [22], [23], [25], in our studies the use of an IL-18 neutralizing antibody confirms that any observed difference in tumor growth can be attributed to the cytokine and is not due to inherent differences between cell lines. This evidence concerns the gene IL18 and neoplasm.