[29]. In another recent study, increased osteopontin plasma levels in MS patients correlated with the bone-specific degradation product C-telopeptide of type-I collagen [30]. However, Altintas et al. [31], by introducing osteopontin as a shared cytokine in the pathogenesis of MS and osteoporosis, reported lower levels of circulating osteopontin in MS patients with osteoporosis at the femoral neck. This evidence concerns the gene SPP1 and myeloid sarcoma.