IL10 and lymphangioleiomyomatosis: Furthermore, inhibiting ERK prior to Ara-LAM treatment in infected macrophages, caused further decrease in STAT3 binding to the IL-10 promoter while inhibition of p38 in Ara-LAM treated macrophages resulted in significant increase in the binding of STAT3 to the IL-10 promoter when compared to only Ara-LAM treated infected sets (figure 3E).