Indeed, chronic esophageal damage from reflux of gastro-duodenal contents can result in the aberrant expression of Cdx2 in the esophageal foregut epithelium and, together with other molecular changes, promotes metaplasia of the cells to an intestinal phenotype (Barrett's Esophagus) and subsequent adenocarcinoma [24]–[26]. This evidence concerns the gene CDX2 and esophageal adenocarcinoma.