Src homology domain-containing phosphatase 2 (SHP2) (PTPN11) is a non-receptor PTP, which regulates several of the RTK pathways known to be overexpressed in glioblastoma, including EGFR, FGFR and PDGFR (Grossmann et al, 2010). The gene discussed is PDGFRB; the disease is glioblastoma.