Src homology domain-containing phosphatase 2 is well known to extend the half-life of active RAS and increase ERK1/2 signalling downstream of a variety of RTKs, including EGFR, PDGFR and FGFR, all of which have been found to be overexpressed in GBM (Giannini et al, 2005). This evidence concerns the gene EGFR and glioblastoma.