While p53 expression was not affected by SAHA, HIT or the combination, p21 was up-regulated in the sarcoma cell lines by SAHA as well as SAHA+HIT and down-regulated in the osteoblast cell line, correlating well to the observed apoptotic reactions of the sarcoma cell lines in contrast to hFOB1.19. Here, TP53 is linked to sarcoma.