Despite these data, the levels of the hRasGRP4 transcript in the PBMCs of our RA patients was not correlated with the examined clinical features (for example, age, disease duration, DAS28, erythrocyte sedimentation rate (ESR), or serum matrix metalloproteinase 3 (MMP3)) (data not shown). The gene discussed is MMP3; the disease is rheumatoid arthritis.