PICALM and Alzheimer disease: Noticeably, other robust results come from the Alzheimer Disease Genetics Consortium (ADGC) that performed GWAS of late onset AD and accordingly we have now overall ten late onset AD susceptibility loci (APOE, CR1, CLU, PICALM, BIN1, EPHA1, MS4A, CD33, CD2AP and ABCA7) that enhance our understanding of the genetic architecture of AD [43].