However, some candidate CSF biomarkers of inflammation that showed increased levels in AD are TNF-α [76], monocyte chemotactic protein-1 [77], interferon γ-inducible protein 10, IL-8 [78], IL-6 [79], transforming growth factor-β (TGFβ) [80], vascular endothelial growth factor (VEGF) [79] and others but detecting changes of inflammatory molecules in CSF require larger scale of replication in cohorts of patients because of their low levels in the CSF. The gene discussed is TNF; the disease is Alzheimer disease.