Further, the same study revealed genome-wide significance for CD2-associated protein (CD2AP), encoding ephrin receptor A1 (EPHA1) and Siglec-3 (CD33) that is a member of the sialic-acid-binding immunoglobulin-like lectins family and these three loci consisted in a follow-up indicative of association with AD [42]. This evidence concerns the gene EPHA1 and Alzheimer disease.