Interestingly, (i) basal O2− production was similar in all cell types, (ii) apoptotic treatment did not modify O2− production in normal cells, (iii) in CF cells, apoptotic treatment enhanced O2− production, (iv) inhibition of NF-κB pathway reduced apoptosis-induced O2− production in pancreatic CF cells, and (v) in tracheal CF cells, the NF-κB pathway seems to regulate basal production of O2−. Here, NFKB1 is linked to cystic fibrosis.