Similarly, in the current study, our data with the sepsis model showed three types of survival phenotypes: (1) tPA-/-/uPA-/- and plg-/- mice, which cannot form active plasmin, have the highest survival rate, the longest median survival time, and the latest time of onset of death; (2) WT and tPA+/-/uPA+/- mice have the lowest survival rate, the shortest median survival time, and the earliest time of onset of death; and (3) plg+/-, uPA-/-, and tPA-/- mice have intermediate survival rate and time of onset of death. Here, PLG is linked to Sepsis.