Since the promoter regions of TNF-α, IL-8 and COX-2 had also been shown to contain consensus binding motifs for NF-κB. In the present study, we firstly infer that anti-inflammatory effect of IG may be linked with inhibition of multiple pro-inflammatory genes through blockade of IκB/NF-κB pathway in experimental colitis. Here, CXCL8 is linked to colitis.