Prophylactic intervention reversed tumor-suppressed phosphorylation or expression of STAT1 (1.82±0.20 vs. 0.46±0.10, p<0.001) and SOCS1 and suppressed the tumor-induced phosphorylation or expression of STAT3 (0.72±0.24 vs. 3.74±1.07, p<0.05) and SOCS3 in the lung tissues. The gene discussed is STAT3; the disease is neoplasm.