In order to utilize up-regulation of DR5 effectively to induce a more potent apoptosis, we treated DLBCL cell lines with a combination of sub-toxic doses of Resveratrol (10 μM) and TRAIL (1 and 5ng) for 24 hours and assessed the apoptotic response. This evidence concerns the gene TNFRSF10B and diffuse large B-cell lymphoma.