In addition, immuno-blot analysis also showed that there was up-regulation of DR5 in SUDHL4 and HBL-1 cells transfected with scrambled siRNA following Resveratrol treatment, however, the expression of DR5 in DLBCL cells transfected with siRNA against DR5 was diminished or absent even after treatment with Resveratrol (Figure 6E). Here, TNFRSF10B is linked to diffuse large B-cell lymphoma.