We confirmed these finding by knocking down expression of DR5 in DLBCL cell lines, Resveratrol was still able to induce efficient apoptosis as was evident by flow cytometry results and immuno-blotting that showed activation of caspases and cleavage of PARP in Resveratrol-treated DLBCL cells. This evidence concerns the gene TNFRSF10B and diffuse large B-cell lymphoma.