Because of the recently established role of RLIP76 as a mediator of CDE through its activity as an ATP-dependent efflux transporter of glutathionylated derivatives of lipid-peroxidation, the established role of CDE in mediating insulin-resistance [23], [24], [40]–[42] and in the context of present findings, we conclude that insulin-resistance should result from an abundance of RLIP76, as occurs under stress-conditions. Here, RALBP1 is linked to Insulin resistance.