Of these 12 genes, 7 genes highly expressed in gastric cancer tissues were down-regulated (ITGB5, TYMS, MYB, APOC1, CBX5, PLA2G2A, KIF20A) and 5 low-expressed genes were up-regulated after vorinostat treatment (SCGB2A1, TCN1, CFD, APLP1, NQO1 (Table 3). The gene discussed is MYB; the disease is gastric cancer.