In contrast, vorinostat treatment also increased the expression of genes which are normally low in human gastric cancer tissue, such as SCGB2A1, TCN1, CFD, APLP1, and NQO1. CFD, known to be important in immune defense in tissue [48], possibly participates in inflammation of gastric epithelium [49]. This evidence concerns the gene SCGB2A1 and gastric cancer.