Thus, EBI3 immunohistochemistry, possibly in conjunction with c-myc staining, performed routinely in all cases of BL, DL/DLBCL and DLBCL, could not only help to discriminate BL and DLBCL, but also be useful to identify cases of BL/DLBCL and DLBCL with potential c-myc translocation and target these cases for further cytogenetic analysis by FISH. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.