ATF-126 and in less extent Maspin cDNA +DOX cells up-regulated the protein gamma-4 subunit/guanine nucleotide-binding protein 4 (GNG4) gene, a brain-specific protein [37] with potential tumor suppressor activity, which, like Maspin[38], is up-regulated by hypoxia factors [39]. Here, SERPINB5 is linked to neoplasm.