The above phenotypic consequences of ATF-126 reactivation, inhibition of tumor growth and metastatic potential as well as gain of epithelial features, are all consistent with the documented functions of the target gene Maspin. The fact that both the Maspin shRNA and the Maspin siRNA were able to rescue the cell growth phenotype in ATF-126 transduced cells demonstrated that the phenotype of ATF-transduced cells was dependent on Maspin, and not on potential off target effects. The gene discussed is SERPINB5; the disease is neoplasm.