NOTCH2 and adenoviridae infectious disease: Thus, transient overexpression of MiR-34a, using both transfection and adenovirus infection, inhibits Notch 2 activation, which reduces the levels of the NICD2 protein in the high-cell-density context, but which does not occur at the low cell density (Fig. 2C) further suggesting the existence of additional mechanisms controlled by miR34a that might be due an activation of Notch2 “cell autonomous signaling”.