Of these, Mlc1 deserves particular attention for its potential function in postnatal progenitors, as mutations in Mlc1 lead to the chronic demyelinating disorder Megalencephalic leukoencephalopathy with Subcortical Cysts- a disease that features an over-production of neural cells early during the first year of life that results in a paucity of myelin and macrocephaly [27]. This evidence concerns the gene MLC1 and leukoencephalopathy, megalencephalic.