MAPK3 and Sepsis: To investigate the signaling mechanisms by which H2S regulates TRPV1-mediated neurogenic inflammation in sepsis, we evaluated the ERK1/2 and NF-κB signaling pathways, with the usage of capsazepine, using two different and complementary approaches: exogenous administration of NaHS as an H2S donor and inhibition of endogenous H2S formation by PAG.