In the context of our mathematical model, the differences between the respective animal studies [12], [13] can be accounted for by the differential ability of NF1 and/or TP53 to induce a (short-lived) gamma effect in cells such that under certain circumstances, a TA cell may be able to serve as the cell of origin for this subtype of glioma. The gene discussed is TP53; the disease is central nervous system cancer.