In the light of all these findings, we designed G4-decoys mimicking HRAS G-quadruplexes, which show a strong antiproliferative activity in T24 urinary bladder cancer cells harboring mutant HRAS. We hypothesized that the G4-decoys should take MAZ away from the promoter and inhibit HRAS transcription. The gene discussed is HRAS; the disease is urinary bladder cancer.