Based on our cytotoxicity study, we evaluated the anti-tumor effects of single MAb C595 in LD (5 mg/kg) and HD (10 mg/kg) after 3 weeks cell inoculation in OVCAR-3 model and found that both LD and HD only partially prevented the production of ascites and reduced tumor weight at the end of experiments compared with the same amounts of MAb IgG3 control. The gene discussed is IGHG3; the disease is neoplasm.