Although there have been a few genetic markers that have associated with an increase risk of seronegative RA, such as HLA-DR1*03 [50], HLA-DR3 [51], and allelic forms of DCIR[52] and IRF5[53], there may be as yet undiscovered loci that predict the seronegative RA phenotype. The gene discussed is CLEC4A; the disease is rheumatoid arthritis.