The variant allele for TLR2-rs3804099 was associated with an increased risk (OR = 1.15, 95% CI 0.99–1.34, p = 0.07) and for TLR4-rs2149356 with a decreased risk (OR = 0.85, 95% CI 0.73–1.00, p = 0.06) of melanoma. This evidence concerns the gene TLR4 and melanoma.