To elucidate the functional relevance of GADD45 α and γ and mda-7/IL-24 for NSAID-mediated JNK induction and apoptosis in ovarian cancer, JNK kinase activity was tested in protein extracts obtained from CAOV-3 cells treated with Sulindac Sulfide and Diclofenac and infected with lentivirus encoding siRNA against GADD45 α and mda-7/IL-24 genes. The gene discussed is MAPK8; the disease is ovarian cancer.