At baseline, patients with type 2 diabetes demonstrated increased plasma glucose and HbA1c when compared to subjects with NGT, while groups were similar with regard to age and BMI, fasting plasma insulin, and NF-κB p65 DNA binding activity, IκBα abundance, p-AMPK, p-ACC, and TNFα and IL-6 mRNA expression in skeletal muscle (Table 1). The gene discussed is TNF; the disease is type 2 diabetes mellitus.