IFNA1 and diabetes mellitus: Considering IFNα has been described to negatively regulate IL-12 production [42] and our findings that diabetes induction is independent of IL-12 when autoreactive T cells are activated when IFNα is significantly represented in the cytokine milieu (with LCMV infection or Poly I∶C stimulation), the possibility arises that IFNα induction is critical and may overcome the requirement for IL-12 in LPS matured DCs.