Although nearly a quarter of RIP-gp/p40+/+ hosts receiving LPS plus IFNα matured p40−/−DCs became diabetic, the effect of IFNα on diabetes induction had the most impact when RIP-gp/p40+/+ mice were given IFNα 3 days after treatment with LPS matured or LPS plus IFNα matured p40−/−DC (Figure 5B). Here, IFNA1 is linked to diabetes mellitus.