IFNA1 and Autoimmunity: Furthermore, in lethally irradiated RIP-gp mice reconstituted with IFNαR−/− bone marrow, treatment with LPS stimulated p40−/− BMDCs followed by the administration of IFNα 3 days later induced autoimmunity with similar kinetics and incidence of disease compared to RIP-GP/p40+/+ mice reconstituted with IFNαR+/+ bone marrow (Figure 5C).