Querying a microarray-based gene expression dataset from skin biopsies from patients with localized and systemic forms of scleroderma and healthy controls showed that the “Egr-1-regulated gene signature” was most prominent in skin biopsies clustering within the “diffuse-proliferation” intrinsic subsets of SSc biopsies, but some of the genes were also associated with “inflammatory” subset. The gene discussed is EGR1; the disease is scleroderma.