Activation of the TBK1/IKKε-dependent pathway following infection of HEK293 cells with Sendai virus (outlined in Figure 4A) was inhibited by C6 (Figure 4B), as was the activation of IRF7 by the downstream signalling components MAVS, TBK1 and IKKε (Figure 4C, D). The gene discussed is MAVS; the disease is infection.