Upon RNAi silencing of the ESCRT proteins Hrs, Tsg101, Vps22, and Vps24, as well as Alix, infection of the α-DG-independent LCMV WE22 was affected to a similar extent as the α-DG-dependent viruses LCMV WE54, LCMV cl-13, and rLCMV-LASVGP. The gene discussed is PDCD6IP; the disease is infection.