The immunoexpression of TLR9 was common in every histological subtype of RCC and immunopositivity for TLR9 was detected in 100 (82%), 6 (67%), 4 (80%) and 2 (100%) cases tumours representing the histological subtypes of clear cell RCC, papillary RCC, chromophobe RCC and unclassified RCC, respectively. The gene discussed is TLR9; the disease is neoplasm.