In neuroblastoma, TLR9 expression has been found to correlate inversely with disease stage [25] whereas in glioma, TLR9 expression has shown to be significantly higher in high grade tumours compared to low-grade gliomas and TLR9 immunoexpression has been reported to be a statistically significant marker of poorer prognosis in glioma [26]. Here, TLR9 is linked to central nervous system cancer.