TNF and Leber congenital amaurosis: Since LCA is a neoplasm arising from the lining cells, the spleen's macrophages, this could also be an area of increased production of TNF-α, eventually contributing to the pathogenesis of LCA, since inflammatory cells including TNF-α are known to have powerful effects on tumor development, producing an attractive environment for tumor growth by facilitating genomic instability and promoting angiogenesis.