Our results not only give a significant contribution to the identification of cases not effectively responsive to the available therapies, but also suggest several potential strategies for the development of novel therapies to treat breast tumors or other epithelial cancers expressing mutp53 and high Pin1 levels, as for example preventing mutp53 phosphorylation and/or interaction with Pin1 as well as down-regulating the 10 signature genes. Here, PIN1 is linked to breast neoplasm.