TARDBP and amyotrophic lateral sclerosis: Linkage analysis of kindreds affected with multiple cases of ALS, FTD, and FTD-ALS with type 2 TDP-43 pathology had suggested there was an important locus for the disease on chromosome 9p (Boxer et al., 2011; Morita et al., 2006; Pearson et al., 2011; Vance et al., 2006) but it had not been clear whether the linkage and association signals related to a single locus or whether the different studies were reporting the same alleles at that locus.