Pharmacological targeting of Dll4-Notch signaling in preclinical tumor models has been achieved by several different mechanisms including anti-Dll4 antibodies, DNA vaccination, soluble Dll4-Fc and Notch-Fc decoys, Notch antibodies, and γ-secretase inhibitors [24,28,30,31,37,41,67,68]. This evidence concerns the gene DLL4 and neoplasm.