Suppression of EphrinB2 signaling using soluble EphrinB2-Fc in a subcutaneous squamous cell carcinoma model phenocopied the effects of Dll4 blockade, in particular, reduced tumor growth accompanied by the induction of non-productive angiogenesis [63], suggesting that EphrinB2 acts as a downstream mediator of Dll4/Notch function. This evidence concerns the gene DLL4 and squamous cell carcinoma.