HSD3B1 and Hypertension: Rosmond et al. [51] proposed that genetic variation in HSD3B1 might lead to an elevation in plasma aldosterone (one of the mineralocorticoids, which are downstream products of progestogens), with a resultant increase in intravascular volume and hypertension, and they did prove the rs6203 silent substitution in exon 4 of HSD3B1 was associated with elevated blood pressure in a population of Swedish men.