INS and fatty liver disease: The major findings include the following: (1) exercise treatment reversed preexisting hepatic steatosis in association with elevated hepatic complete FAO and CPT-1 activity, improved systemic insulin sensitivity, and decreased markers of hepatic lipogenesis; (2) n3PUFAs supplemented at 3% of diet increased TAG accumulation in the liver and, when combined with exercise n3PUFAs, did not lead to additive health benefits, but instead partially blunted the beneficial effects of exercise to reduce hepatic TAG accumulation and improve insulin sensitivity.