MAPT and Alzheimer disease: The triple transgenic mouse model of Alzheimer's disease (3xTgAD) mouse developed by Oddo, LaFerla and colleagues bears mutations in three genes (human APPSWE, TauP301L, and PS1M146V genes) linked to AD and fronto-temporal dementia and exhibits an age-related neuropathological phenotype including both Aβ deposition and tau hyperphosphorylation [5].