AKAP12 and colorectal carcinoma: In our previous study, downregulation or loss of AKAP12 mRNA expression was detected in 68.9% (31/45) of colorectal carcinoma tissues and methylation of the AKAP12 promoter region was detected in 77.8% (35/45) of these tissues compared with 13.3% (6/45) in the adjacent tissue[13].