In autosomal dominant hyper-IgE syndrome (AD-HIES) hypomorphic mutations in STAT3 (signal transducer and activator of transcription) gene has been demonstrated [54], leading to impaired Th17 cells differentiation and defective multiple cytokine signaling, resulting in impaired upregulation of antimicrobial peptides [55]. This evidence concerns the gene STAT3 and Autosomal dominant hyper-IgE syndrome.