Similarly, in ob/ob (leptin deficient) mice, which are hyperphagic, develop insulin resistance and have severe steatosis [48], an adiponectin transgene (which restored normal serum adiponectin levels) expanded subcutaneous adipose and worsened obesity, but improved metabolic indices, such as glycemic control, in association with amelioration of NAFLD [72]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.