IRS1 and type 2 diabetes mellitus: This variant, together with rs2943641 near IRS1, was independently associated with T2D risk in WHII using a variable selection model with adjustment for age, gender and BMI (OR: 0.50, 95%CI: 0.33–0.78, p = 0.002 and OR: 0.82, 95%CI: 0.69–0.99, p = 0.04, respectively) and appeared to have an additive effect on risk.