IRS1 and diabetes mellitus: The Diabetes Genetics Replication and Meta-analysis Consortium (DIAGRAM) in an earlier meta-analysis did not identify this SNP as a T2D risk variant [4]; however, in a subsequent publication [6] a different IRS1 SNP (rs7578326) adjacent to and in strong linkage disequilibrium (LD) with rs2943641 (r2 = 0.79, in HapMap CEU) was reported to be associated with T2D.