IRS1 and type 2 diabetes mellitus: Using a variable selection model including all risk-associated IRS1 variants, age, gender and BMI considered for entry, we identified that rs6725556 (OR per minor G-allele: 0.50, 95%CI: 0.33–0.78, p = 0.002) and SNP rs2943641 near IRS1 (OR per minor T-allele: 0.82, 95%CI: 0.69–0.99, p = 0.04) were the only variants that were independently associated with T2D risk in WHII, along with age (p < 0.001) and BMI (p < 0.001).