TET2 and acute myeloid leukemia: Metzeler et al. [21] recently analyzed 427 patients with CN-AML, and revealed that TET2 mutations were detected in 95 of 418 (23%) of the patients, and associated with older age (p < 0.001) and higher pretreatment white blood cell counts (p = 0.04) compared with wild-type TET2.