In analyses involving 353 adult de novo AML patients, Carnicer et al. [60] found cooperative mutations of FLT3-TKD with CBFβ/MYH11 rearrangement (4 of 15 patients) and C/EBPα with FLT3-ITD (2 of 82 patients). The gene discussed is FLT3; the disease is acute myeloid leukemia.