DHA induces apoptosis of neuroblastoma cells due to its conversion to 17-hydroxydocosahexaenoic acid (17-HDHA) via 17-hydroperoxydocosahexaenoic acid (17-HpDHA) through 15-lipoxygenase and autoxidation [82] and as a result tumor cells do not produce (or form negligible amounts) of the anti-inflammatory lipid mediators such as resolvins and protectins. The gene discussed is ALOX15B; the disease is neuroblastoma.