Fourth, genome-wide promoter analysis using chromatin immunoprecipitation (ChIP) combined with chip technology (ChIP-chip) of the SOX4 transcriptional network in human prostate cancer cells has identified ZNF281 as one of the direct transcriptional targets of SOX4, a critical developmental transcription factor required for precise differentiation and proliferation in multiple tissues and dysregulated in many types of human cancers [22]. This evidence concerns the gene SOX4 and prostate cancer.