Biomarker combinations that show promise as future diagnostic or prognostic panels for early RA include anti-CCP, anti-MCV, and IgM-RF [66], anti-CCP and matrix metalloproteinases 3 (MMP-3) [169], and anti-CCP, MMP-3 and high-sensitivity CRP (hsCRP) [170]. This evidence concerns the gene MMP3 and rheumatoid arthritis.