AGT and Hypertension: In hypertension, Ang II may enhance basal superoxide production in the vasculature by activation of reduced NADPH (Nicotinamide Adenine Dinucleotide Phosphate) oxidase and expression of its subunits via cSrc, PKC (Protein Kinase C), PLA2 (Phospholipase A2), and PLD (Phospholipase D) pathways [38–41].