In the present study, we have initially confirmed the potential role of BMC-mediated IL-10 gene delivery in preventing the progression of atherosclerosis, with histological evidence showing that the NWI is significantly lower in the study group with transplantation of IL-10 BMCs in comparison to the control groups transplanted with Feridex-BMCs or without BMC transplantation. Here, IL10 is linked to atherosclerosis.